Article Details


The Quest for Novel Biomarkers in Early Diagnosis of Diabetic Neuropathy

[ Vol. 14 , Issue. 2 ]

Author(s):

Mihaela Adriana Ghita, Constantin Caruntu, Daniela Lixandru, Adriana Pitea, Alexandra Batani and Daniel Boda   Pages 86 - 99 ( 14 )

Abstract:


Diabetic neuropathy is the most common complication of diabetes mellitus and a major factor associated with foot ulcers and amputations in patients with diabetes. Diagnosing diabetic neuropathy in early stages may reduce the risk for comorbidities. However, it still represents a major challenge for the healthcare providers, despite the complexity of available techniques. Discovering new serum biomarkers, useful for early diagnosis of diabetic neuropathy and monitoring the disease progression is of growing interest for the scientific research. In this regard, the field of proteomics is extremely promising. Mass spectrometry technology and bioinformatic analysis of proteomic data accelerated the detection of biomarkers related to peripheral nervous system pathology. Herein, we analyze what role proteomics approaches play in the modern diagnostic strategy of diabetic neuropathy.

Keywords:

Biomarker, diabetes, diabetic neuropathy, diagnosis, mass spectrometry, proteomics.

Affiliation:

Dermatology Research Laboratory, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Department of Physiology, “Carol Davila” University of Medicine and Pharmacy, 050474, Bucharest, Biochemistry Department, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Institute of Computational Biology, Helmholtz Zentrum München, Dermatology Research Laboratory, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Dermatology Research Laboratory, “Carol Davila” University of Medicine and Pharmacy, Bucharest

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