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Multi-epitope Vaccines (MEVs), as a Novel Strategy against Infectious Diseases

Author(s):

Shirin Mahmoodi*, Ibrahim Farhani, Mohammad Mahmoodi Goumari and Navid Nezafat   Pages 1 - 12 ( 12 )

Abstract:


Infectious diseases have caused historical pandemics in the world. Three strategies, including sanitation programs, antimicrobial drugs, and vaccines are considered for prevention and treatment of infectious diseases. Today, some infectious diseases have been caused millions of mortalities universally. Due to the emergence of antibiotic-resistant pathogens, as well as some limitations of traditional vaccines, focusing on novel strategies is essential. multi-epitope vaccines (MEVs) as a novel strategy is designed based on immunoinformatics methods; Epitope prediction by authentic servers, attachment of epitopes using proper linkers, physicochemical, immunological and structural evaluation by bioinformatics tools are basic stages in MEVs designing. Specialty, cost-effective, high safety, time-saving in designing, the applying of natural adjuvant, and satisfying preclinical evaluation outstand MEVs than other types of vaccines. Therefore, MEVs are promising vaccine against resistant diseases such as lower respiratory infection and diarrhea.

Keywords:

Epitope, Infectious diseases, Reverse vaccinology, Vaccine designing, diarrhea, safe water

Affiliation:

Department of Medical Biotechnology, School of Medicine, Fasa University of Medical Sciences, Fasa, Department of Medical Biotechnology, School of Medicine, Fasa University of Medical Sciences, Fasa, Department of Medical Biotechnology, Faculty of Allied Medical Sciences, Iran University of Medical Sciences, Shiraz University of Medical Sciences, Pharmaceutical Sciences Research Center, Shiraz



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