Mohammad Mahmoudi Goumari , Ibrahim Farhani, Navid Nezafat and Shirin Mahmoodi* Pages 354 - 364 ( 11 )
Infectious diseases have caused historical pandemics in the world. Three strategies, including sanitation programs, antimicrobial drugs, and vaccines are considered for the prevention and treatment of infectious diseases. Today, some infectious diseases cause millions of mortalities universally. Due to the emergence of antibiotic-resistant pathogens, as well as some limitations of traditional vaccines, focusing on novel strategies is essential. Multi-Epitope Vaccines (MEVs), as a novel strategy, have been designed based on immunoinformatics methods; epitope prediction by authentic servers, attachment of epitopes using proper linkers, physicochemical, immunological and structural evaluation by bioinformatics tools that are basic stages in MEVs designing. Advantages such as cost-effective, high safety, less time consumption in designing, the application of natural adjuvants, and satisfactory preclinical evaluation outstand MEVs than other types of vaccines. Therefore, MEVs are promising vaccines against resistant diseases such as lower respiratory infection and diarrhea.
Epitope, infectious diseases, vaccine designing, bioinformatics, Multi-epitope vaccines (MEVs), antimicrobial drugs.
Department of Medical Biotechnology, Faculty of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Department of Medical Biotechnology, School of Medicine, Fasa University of Medical Sciences, Fasa, Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Department of Medical Biotechnology, School of Medicine, Fasa University of Medical Sciences, Fasa