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Distorted Key Theory and Its Implication for Drug Development


Kuo-Chen Chou*   Pages 1 - 15 ( 15 )


During the last three decades or so, many efforts have been made to study the protein cleavage sites by some disease-causing enzyme, such as HIV (human immunodeficiency virus) protease and SARS (severe acute respiratory syndrome) coronavirus main proteinase. It has become increasingly clear via this minireview that the motivation driving the aforementioned studies is quite wise, and that the results acquired through these studies are very rewarding, particularly for developing peptide drugs.


HIV; SARS; Protein cleavage sites; Lock and key; Induced fit theory; Rack mechanism; Peptide drug


Gordon Life Science Institute, Boston, Massachusetts 02478

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