Kuo-Chen Chou* Pages 311 - 323 ( 13 )
During the last three decades or so, many efforts have been made to study the protein cleavage sites by some disease-causing enzyme, such as HIV (human immunodeficiency virus) protease and SARS (severe acute respiratory syndrome) coronavirus main proteinase. It has become increasingly clear via this mini-review that the motivation driving the aforementioned studies is quite wise, and that the results acquired through these studies are very rewarding, particularly for developing peptide drugs.
HIV; SARS; Protein cleavage sites; Lock and key; Induced fit theory; Rack mechanism; Peptide drug
Gordon Life Science Institute, Boston, MA 02478