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Distorted Key Theory and Its Implication for Drug Development

[ Vol. 17 , Issue. 4 ]


Kuo-Chen Chou*   Pages 311 - 323 ( 13 )


During the last three decades or so, many efforts have been made to study the protein cleavage sites by some disease-causing enzyme, such as HIV (human immunodeficiency virus) protease and SARS (severe acute respiratory syndrome) coronavirus main proteinase. It has become increasingly clear via this mini-review that the motivation driving the aforementioned studies is quite wise, and that the results acquired through these studies are very rewarding, particularly for developing peptide drugs.


HIV; SARS; Protein cleavage sites; Lock and key; Induced fit theory; Rack mechanism; Peptide drug


Gordon Life Science Institute, Boston, MA 02478

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