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Distorted Key Theory and its Implication for Drug Development

[ Vol. 17 , Issue. 4 ]

Author(s):

Kuo-Chen Chou*   Pages 311 - 323 ( 13 )

Abstract:


During the last three decades or so, many efforts have been made to study the protein cleavage sites by some disease-causing enzyme, such as HIV (Human Immunodeficiency Virus) protease and SARS (Severe Acute Respiratory Syndrome) coronavirus main proteinase. It has become increasingly clear via this mini-review that the motivation driving the aforementioned studies is quite wise, and that the results acquired through these studies are very rewarding, particularly for developing peptide drugs.

Keywords:

HIV, SARS, protein cleavage sites, lock and key, induced fit theory, rack mechanism, peptide drugs.

Affiliation:

Gordon Life Science Institute, Boston, MA 02478

Graphical Abstract:



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