Submit Manuscript  

Article Details


Distorted Key Theory and Its Implication for Drug Development

[ Vol. 17 , Issue. 4 ]

Author(s):

Kuo-Chen Chou*   Pages 311 - 323 ( 13 )

Abstract:


During the last three decades or so, many efforts have been made to study the protein cleavage sites by some disease-causing enzyme, such as HIV (human immunodeficiency virus) protease and SARS (severe acute respiratory syndrome) coronavirus main proteinase. It has become increasingly clear via this mini-review that the motivation driving the aforementioned studies is quite wise, and that the results acquired through these studies are very rewarding, particularly for developing peptide drugs.

Keywords:

HIV; SARS; Protein cleavage sites; Lock and key; Induced fit theory; Rack mechanism; Peptide drug

Affiliation:

Gordon Life Science Institute, Boston, MA 02478



Read Full-Text article