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Unique Ncov-2019 (Covid-19) Spike Glycoprotein Processing by Host Protease: Analysis and Implication on Infection

Author(s):

Ajoy Basak* and Sarmistha Basak   Pages 1 - 8 ( 8 )

Abstract:


The current global pandemic outbreak of a novel type of corona virus termed by World Health Organization as COVID-19 became an grave concern and worry to human health and world economy. Intense research efforts are now underway worldwide to combat and prevent the spread of this deadly disease. This zoonotic virus, a native to bat population is most likely transmitted to human via a host reservoir. Due to its close similarity to previously known SARS CoV (Severe Acute Respiratory Syndrome Corona Virus) of 2002 and related MERS CoV (Middle East Respiratory Syndrome Corona Virus) of 2012, it is also known as SARS CoV2. But unlike them it is far too infectious, virulent and lethal. Among its various proteins, the surface spike glycoprotein ā€œSā€ has drawn significant attention because of its implication in viral recognition and host-virus fusion process. A detail comparative analysis of ā€œSā€ proteins of SARS CoV (now called SARS CoV1), SARS CoV2 (COVID-19) and MERS CoV based on structure, sequence alignment, host cleavage sites, receptor binding domains, potential glycosylation and Cys-disulphide bridge locations has been performed. It revealed some key features and variations that may elucidate the high infection and virulence character of COVID-19. Moreover this crucial information may become useful in our quest for COVID-19 therapeutics and vaccines.

Keywords:

nCoV-2019, COVID-19, SARS CoV1, SARS CoV2, MERS CoV, spike glycoprotein, processing, host protease, furin, receptor, cleavage site, glycosylation sites, disulfide bonds

Affiliation:

Pathology and Laboratory Medicine, Faculty of Medicine, U Ottawa, Formerly of Kidney Research Center, Ottawa Hospital Research Institute, U Ottawa



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