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Neurochemical Changes in the Brain After Fetal Exposure to Fluoxetine, A Serotonin Reuptake Inhibitor (SRI) in Rodents

[ Vol. 18 , Issue. 4 ]

Author(s):

Mona A. Alonazi, Amina El Gezeery, Afaf El-Ansary and Ramesa S. Bhat*   Pages 499 - 504 ( 6 )

Abstract:


Background: In utero exposure to Selective Serotonin Reuptake Inhibitors (SSRI) is considered a risk factor for many neurodevelopmental diseases.

Objective: The aim of this study was to investigate whether prenatal SSRI exposure changes newborn brain chemistry .

Methods: An animal-based study was designed in which the utero SSRI exposed rat pups were compared to one without drug exposure. Neurochemical changes in the infants were assessed after 2 days of birth by estimating the levels of inflammatory cytokines, neurotransmitters, and caspases in the brain exposed to SSRI at the prenatal stage and compared to normal unexposed newborns.

Results: Our results showed significant neurochemical changes in SSRI-exposed newborns. A significant decrease in dopamine, and serotonin levels with a remarkable decrease in noradrenaline in addition to remarkable increase of IFN-γ and caspase-3 levels was observed in the brain tissues of prenatal exposed SSRIs rat pups.

Conclusion: The results suggest that prenatal SSRI treatment may affect brain development of newborn hence should be done warily during the gestation period.

Keywords:

Depression, neurotransmitters, pro-inflammatory cytokines, caspases, brain, SSRI.

Affiliation:

Biochemistry Department, College of Science, King Saud University, Riyadh, Biochemistry Department, College of Science, King Saud University, Riyadh, Central Laboratory, Female Centre for Scientific and Medical Studies, King Saud University, Riyadh, Biochemistry Department, College of Science, King Saud University, Riyadh



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